課程名稱 |
高等化學生物學二 Advanced Chemical Biology(Ⅱ) |
開課學期 |
99-2 |
授課對象 |
生命科學院 生化科學研究所 |
授課教師 |
林俊宏 |
課號 |
Chem7036 |
課程識別碼 |
223 M1620 |
班次 |
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學分 |
3 |
全/半年 |
半年 |
必/選修 |
必修 |
上課時間 |
星期五2,3,4(9:10~12:10) |
上課地點 |
化121 |
備註 |
本課程中文授課,使用英文教科書。化學系有機組不得修習。化學系化生組3選1必修。 限碩士班以上 總人數上限:50人 |
Ceiba 課程網頁 |
http://ceiba.ntu.edu.tw/992Chem7036 |
課程簡介影片 |
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核心能力關聯 |
核心能力與課程規劃關聯圖 |
課程大綱
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課程概述 |
This courses aims to provide students with general knowledge in the synthesis of biomolecules, which is applied either to prepare small molecules to probe target DNA/proteins, or to develop efficient methods to study biological questions. Therefore seven weeks are used to cover the synthesis, while the remaining is to talk about famous examples. Students who want to take the course need to pass the undergraduate course of organic chemistry (two semester courses with at least 2 hours per week). |
課程目標 |
It is also recommended to have basic concept in biochemistry, at least to be aware of what are the structures of amino acids, nucleic acids and sugars. |
課程要求 |
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預期每週課後學習時數 |
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Office Hours |
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指定閱讀 |
(1) Chemical Biology: A practical course (by Waldmann, H.; Janning P.), Wiley-VCH, 2004.
(2) Chemical Biology: Learning through case studies (by Waldmann, H.; Janning P.), Wiley-VCH, 2009.
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參考書目 |
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評量方式 (僅供參考) |
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週次 |
日期 |
單元主題 |
第1週 |
2/25 |
General Information |
第2週 |
3/04 |
Carbohydrate synthesis: protection chemistry (II)-Chap 15 |
第3週 |
3/11 |
Take one day off |
第4週 |
3/18 |
Carbohydrate synthesis: glycosylation |
第5週 |
3/25 |
Solid phase peptide synthesis |
第6週 |
4/1 |
Synthesis of Nucleic acids |
第7週 |
4/08 |
Native Chemical ligation |
第8週 |
4/15 |
Combinatorial synthesis and compound collections for chemical biology |
第9週 |
4/22 |
Activity-based protein profiling (1) |
第10週 |
4/29 |
Activity-based protein profiling (2) |
第11週 |
5/06 |
Specific cell imaging in vivo (1) |
第12週 |
5/13 |
Specific cell imaging in vivo (2) |
第13週 |
5/20 |
To target specific kinases of interest (1) |
第14週 |
5/27 |
To target specific kinases of interest (2) |
第15週 |
6/03 |
Ras proteins & signalling |
第17週 |
06/17 |
Final exam (optional) |
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